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Lei Chen Selected Research

Interleukin-6 (Interleukin 6)

3/2024Cold atmospheric plasma for chronic kidney disease-related skin disorders.
1/2024Zhoushi Qi Ling decoction inhibits the progression of castration-resistant prostate cancer in vivo by regulating macrophage infiltration via IL6-STAT3 signaling.
1/2024Semaglutide alleviates early brain injury following subarachnoid hemorrhage by suppressing ferroptosis and neuroinflammation via SIRT1 pathway.
6/2023NLRP3 in tumor-associated macrophages predicts a poor prognosis and promotes tumor growth in head and neck squamous cell carcinoma.
1/2023Astragaloside IV alleviates stroke-triggered early brain injury by modulating neuroinflammation and ferroptosis via the Nrf2/HO-1 signaling pathway.
1/2023Interleukin 6 exacerbates the progression of warm autoimmune hemolytic anemia by influencing the activity and function of B cells.
1/2023Zhoushi Qiling decoction inhibits proliferation of human prostate cancer cells through IL6/STAT3 pathway.
1/2022Therapeutic targets and signaling pathways of active components of QiLing decoction against castration-resistant prostate cancer based on network pharmacology.
1/2022SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
1/2022Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
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Lei Chen Research Topics

Disease

632Neoplasms (Cancer)
05/2024 - 10/2003
146Inflammation (Inflammations)
03/2024 - 06/2008
115Hepatocellular Carcinoma (Hepatoma)
05/2024 - 09/2004
114Nasopharyngeal Carcinoma
12/2023 - 07/2011
109Neoplasm Metastasis (Metastasis)
02/2024 - 11/2006
96Infections
04/2024 - 03/2007
64Glioma (Gliomas)
12/2023 - 05/2009
60Wounds and Injuries (Trauma)
04/2024 - 04/2008
54Carcinogenesis
11/2023 - 10/2003
51Stomach Neoplasms (Stomach Cancer)
02/2024 - 12/2004
45Prostatic Neoplasms (Prostate Cancer)
01/2024 - 11/2013
41Obesity
05/2024 - 04/2004
41COVID-19
03/2024 - 01/2020
38Pain (Aches)
12/2023 - 01/2005
37Parkinson Disease (Parkinson's Disease)
05/2024 - 08/2004
37Hypoxia (Hypoxemia)
10/2023 - 04/2006
36Body Weight (Weight, Body)
05/2024 - 06/2005
36Breast Neoplasms (Breast Cancer)
02/2024 - 12/2005
36Type 2 Diabetes Mellitus (MODY)
01/2024 - 01/2004
35Fibrosis (Cirrhosis)
03/2024 - 07/2009
34Schizophrenia (Dementia Praecox)
05/2024 - 01/2008
34Epilepsy (Aura)
01/2024 - 09/2003
32Colorectal Neoplasms (Colorectal Cancer)
01/2024 - 11/2006
32Chronic Obstructive Pulmonary Disease (COPD)
01/2023 - 07/2009
31Glioblastoma (Glioblastoma Multiforme)
12/2023 - 01/2013
30Insulin Resistance
12/2023 - 01/2004
29Alzheimer Disease (Alzheimer's Disease)
05/2024 - 01/2008
28Squamous Cell Carcinoma of Head and Neck
05/2024 - 08/2016
28Hemorrhage
04/2024 - 04/2006
28Liver Neoplasms (Liver Cancer)
01/2024 - 09/2007
27Stroke (Strokes)
05/2024 - 06/2009
27Melanoma (Melanoma, Malignant)
05/2024 - 06/2008
26Cognitive Dysfunction
04/2024 - 08/2014
25Lung Neoplasms (Lung Cancer)
07/2023 - 10/2008
24Adenocarcinoma
04/2024 - 05/2004
22Necrosis
11/2023 - 07/2009
22Carcinoma (Carcinomatosis)
07/2023 - 09/2004
21Ischemic Stroke
05/2024 - 11/2011
20Atherosclerosis
01/2023 - 01/2016
20Multiple Myeloma
01/2023 - 12/2007
19Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
02/2024 - 08/2011
19Lymphatic Metastasis
02/2024 - 02/2008
19Cicatrix (Scar)
12/2023 - 11/2011
19BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2021 - 07/2012
18Hypertension (High Blood Pressure)
03/2024 - 08/2006
18Cardiovascular Diseases (Cardiovascular Disease)
01/2024 - 09/2008
17Neurodegenerative Diseases (Neurodegenerative Disease)
05/2024 - 01/2014
17Neuroinflammatory Diseases
05/2024 - 08/2013
17Heart Failure
03/2024 - 03/2004

Drug/Important Bio-Agent (IBA)

208Proteins (Proteins, Gene)FDA Link
04/2024 - 12/2002
127Biomarkers (Surrogate Marker)IBA
05/2024 - 08/2007
90MicroRNAs (MicroRNA)IBA
11/2023 - 02/2009
63CytokinesIBA
01/2024 - 05/2004
59Glucose (Dextrose)FDA LinkGeneric
01/2024 - 01/2004
54Messenger RNA (mRNA)IBA
08/2023 - 06/2009
53Therapeutic UsesIBA
05/2024 - 01/2005
47RNA (Ribonucleic Acid)IBA
12/2024 - 12/2009
46Long Noncoding RNAIBA
12/2023 - 01/2015
41DNA (Deoxyribonucleic Acid)IBA
01/2024 - 11/2004
41Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2023 - 04/2006
38Interleukin-6 (Interleukin 6)IBA
03/2024 - 02/2004
36LipidsIBA
05/2024 - 04/2004
35CollagenIBA
03/2024 - 03/2005
34Cisplatin (Platino)FDA LinkGeneric
03/2024 - 04/2011
34Reactive Oxygen Species (Oxygen Radicals)IBA
02/2024 - 11/2004
30EnzymesIBA
02/2024 - 08/2003
29Small Interfering RNA (siRNA)IBA
01/2023 - 04/2006
26LigandsIBA
05/2024 - 01/2012
26Peptides (Polypeptides)IBA
05/2023 - 03/2011
25Insulin (Novolin)FDA Link
03/2024 - 04/2004
24CateninsIBA
03/2024 - 06/2008
24Transcription Factors (Transcription Factor)IBA
02/2024 - 05/2009
24SmokeIBA
01/2022 - 07/2009
23Indicators and Reagents (Reagents)IBA
05/2024 - 03/2011
23AntioxidantsIBA
05/2024 - 03/2009
23Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2024 - 12/2007
22Antipsychotic Agents (Antipsychotics)IBA
08/2022 - 01/2008
20Oxygen (Dioxygen)IBA
05/2024 - 04/2006
19C-Reactive ProteinIBA
04/2024 - 08/2006
191-phenyl-3,3-dimethyltriazene (PDT)IBA
11/2023 - 10/2013
19FlavonoidsIBA
06/2023 - 07/2011
19Matrix Metalloproteinases (MMPs)IBA
11/2021 - 05/2007
18Tyrosine Kinase InhibitorsIBA
02/2024 - 01/2009
18AntigensIBA
09/2023 - 02/2009
17VaccinesIBA
03/2024 - 05/2006
17HydrogelsIBA
03/2024 - 01/2012
17Phosphotransferases (Kinase)IBA
02/2024 - 06/2010

Therapy/Procedure

298Therapeutics
05/2024 - 05/2004
98Drug Therapy (Chemotherapy)
02/2024 - 03/2004
73Radiotherapy
01/2024 - 12/2005
51Immunotherapy
03/2024 - 09/2004
48Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
01/2022 - 07/2011
35Chemoradiotherapy
01/2023 - 02/2012
35Induction Chemotherapy
01/2023 - 10/2015
24Chinese Traditional Medicine (Traditional Chinese Medicine)
09/2023 - 01/2005
20Photochemotherapy (Photodynamic Therapy)
11/2023 - 12/2013
20Length of Stay
01/2023 - 02/2008
19Transplantation
11/2023 - 02/2004
19Aftercare (After-Treatment)
08/2023 - 06/2009
17Stents
02/2024 - 08/2011